Article

Phenome-derived polygenic scores and social determinants jointly shape context-dependent disease risk

2026-04-18

Abstract excerpt

Polygenic scores (PGS) are typically derived from single-trait genome-wide association studies (GWAS), yet many complex diseases arise from shared genetic liability distributed across correlated clinical dimensions. Accordingly, disease risk depends not only on how genetic liability is represented but also on the social context in which that liability is expressed. Whether phenome-derived latent factors improve pr...

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Literature Corpus work: 80b9de90-7eff-5bd6-bc42-186c296f6dd3
DOI: 10.64898/2026.04.16.26351039

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