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Revealing polygenic pleiotropy using genetic risk scores for asthma

16 Aug 2023

Abstract excerpt

In this study we examined how genetic risk for asthma associates with different features of the disease and with other medical conditions and traits. Using summary statistics from two multi-ancestry genome-wide association studies of asthma, we modeled polygenic risk scores (PRSs) and validated their predictive performance in the UK Biobank. We then performed phenome-wide association studies of the asthma PRSs...

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PMID: 37663543
DOI: 10.1016/j.xhgg.2023.100233

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