Article
A polygenic risk score for asthma in a large racially diverse population.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Nov 2021
Sordillo Joanne E, Lutz Sharon M, Jorgenson Eric, Iribarren Carlos, McGeachie Michael, Dahlin Amber, Tantisira Kelan, Kelly Rachel, Lasky-Su Jessica, Sakornsakolpat Phuwanat, Moll Matthew, Cho Michael H, Wu Ann Chen
Abstract excerpt
BACKGROUND: Polygenic risk scores (PRSs) will have important utility for asthma and other chronic diseases as a tool for predicting disease incidence and subphenotypes. OBJECTIVE: We utilized findings from a large multiancestry GWAS of asthma to compute a PRS for asthma with relevance for racially diverse populations. METHODS: We derived two PRSs for asthma using a standard approach (based on genome-wide...
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