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Article

Leveraging pleiotropy to improve genetic risk prediction across diseases.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 May 2026

Hu Jiaqi, Zhou Geyu, Zhao Hongyu, DeWan Andrew T

Abstract excerpt

PURPOSE: Polygenic scores (PGSs) have shown promise in predicting disease risk, but their predictive accuracy remains limited for many complex diseases. Leveraging the shared genetic architecture among correlated traits may improve prediction performance. METHODS: We developed a flexible framework for constructing multitrait PGSs by integrating candidate PGSs (N = 2651) derived from 51 genome-wide association...

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Identifiers

PMID: 41800596
DOI: 10.1016/j.gim.2026.102548
PMCID: PMC13221702

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