Article
EndoPRS: Incorporating endophenotype information to improve polygenic risk scores for clinical endpoints-A study in asthma.
American journal of human genetics - 1 May 2025
Kharitonova Elena V, Sun Quan, Ockerman Franklin, Chen Brian, Zhou Laura Y, Hysong Micah R, Tuftin Bjoernar, Cao Hongyuan, Mathias Rasika A, Auer Paul L, Ober Carole, Raffield Laura M, Reiner Alexander P, Cox Nancy J, Kelada Samir N P, Tao Ran, Li Yun
Abstract excerpt
Polygenic risk score (PRS) prediction of complex diseases can be improved by leveraging related phenotypes. This has motivated the development of several multi-trait PRS methods that jointly model genetically correlated traits. However, these methods do not account for vertical pleiotropy, where one trait acts as a mediator for another. Here, we introduce endoPRS, a weighted lasso model that incorporates...
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