PRSet: Pathway-based polygenic risk score analyses and software.

Abstract excerpt

Polygenic risk scores (PRSs) have been among the leading advances in biomedicine in recent years. As a proxy of genetic liability, PRSs are utilised across multiple fields and applications. While numerous statistical and machine learning methods have been developed to optimise their predictive accuracy, these typically distil genetic liability to a single number based on aggregation of an individual's genome-wide...

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• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Genomics
• Multifactorial Inheritance
• Risk Factors