Article

Mechanism of SETX-BRCA1-BARD1 complex in resolution of R-loops and transcription-replication conflicts

2024-01-15

Abstract excerpt

<title>Abstract</title> <p>Senataxin (SETX), a putative RNA-DNA helicase, is recruited to transcription pause sites via the tumor suppressor BRCA1. Here, we define the mechanism by which SETX-BRCA1 resolves transcription-associated R-loops to prevent deleterious outcomes. Specifically, we show that SETX unwinds R-loops, and that the complex of BRCA1 and its obligatory partner BARD1 binds R-loops and stimulates R-...

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Literature Corpus work: 7a0ec83d-16fc-5bd6-856f-19f0380d0c98
DOI: 10.21203/rs.3.rs-3833044/v1

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