Article

R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability

2021-04-26

Abstract excerpt

<title>Abstract</title> <p>Transcription can pose a threat to genomic stability through the formation of R-loops that obstruct the progression of replication forks. R-loops are three-stranded nucleic acid structures formed by an RNA-DNA hybrid with a displaced non-template DNA strand. We developed RDProx to identify proteins that regulate R-loops in human cells. RDProx relies on the expression of the hybrid-bindi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 690b230c-9724-5b7b-8072-8e118d3f5b97
DOI: 10.21203/rs.3.rs-337351/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instabilityDOI 10.21203/rs.3.rs-337351/v1Read

R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instabilitySemantic proximity Read

RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA DamageSemantic proximity Read

Variability in R-loops levels based on IHC detectionSemantic proximity Read

Genome-wide mapping of native co-localized G4s and R-loops in living cellsSemantic proximity Read

DHX9 helicase promotes R-loop formation in cells with impaired RNA splicingSemantic proximity Read

Different alterations in mRNP composition trigger an increase in harmful R-loopsSemantic proximity Read

qDRIP: Quantitative differential RNA:DNA hybrid immunoprecipitation sequencingSemantic proximity Read

Proximity labeling identifies a repertoire of site-specific R-loop modulators.Semantic proximity Read

MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflictsSemantic proximity Read

BisMapR: a strand-specific, nuclease-based method for genome-wide R-loop detectionSemantic proximity Read

Protein-mediated stabilization and nicking of the non-template DNA strand dramatically affect R-loop formation <i>in vitro</i>Semantic proximity Read

Transcription-Coupled Repair and R-Loop Crosstalk in Genome StabilitySemantic proximity Read