Article

Human senataxin is a bona fide R-loop resolving enzyme and transcription termination factor

2022-08-26

Abstract excerpt

<h4>ABSTRACT</h4> Prolonged pausing of the transcription machinery may lead to the formation of three-stranded nucleic acid structures, called R-loops, typically resulting from the annealing of the nascent RNA with the template DNA. Unscheduled persistence of R-loops and RNA polymerases may interfere with transcription itself and other essential processes such as DNA replication and repair. Senataxin (SETX) is a...

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Literature Corpus work: 7b8a046a-dae3-511f-be4e-4fe20f5db3ec
DOI: 10.1101/2022.08.25.505353

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