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Senataxin and R-loops homeostasis: multifaced implications in carcinogenesis

5 May 2023

Abstract excerpt

R-loops are inherent byproducts of transcription consisting of an RNA:DNA hybrid and a displaced single-stranded DNA. These structures are of key importance in controlling numerous physiological processes and their homeostasis is tightly controlled by the activities of several enzymes deputed to process R-loops and prevent their unproper accumulation. Senataxin (SETX) is an RNA/DNA helicase which catalyzes the...

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PMID: 37147318
DOI: 10.1038/s41420-023-01441-x

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