Article
Resolution of R-loops and transcription-replication conflicts by SETX-BRCA1-BARD1 complex.
Nature structural & molecular biology - 1 Apr 2026
Dutta Arijit, Ji Jae-Hoon, Syed Shahrez, Fang Qingming, Mukhopadhyay Pramiti, Wang Hanzhou, Loranc Eva, Medina Daisy, Abdulsahib Shahad, Zhou Shuo, Tovar Miriam, Wang Jeff, Benoit Jane M, Liang Fengshan, Tomimatsu Nozomi, Nyalwidhe Julius O, Dray Eloise, Verway-Cohen Amy, McDonald Drew T, de la Peña Avalos Bárbara, Li Wenjing, Herrero Ane Olazabal, Fitzgerald O'Taveon, Taylor Alexander B, Kwon Youngho, Semmes Oliver J, Tsai Miaw-Sheue, Rao Manjeet, Hromas Robert, Burma Sandeep, Chen Yidong, Mazin Alexander V, Wasmuth Elizabeth, Olsen Shaun K, Zhou Daohong, Bishop Alexander J R, Zhao Weixing, Kupfer Gary M, Sung Patrick
Abstract excerpt
Senataxin (SETX), an RNA-DNA helicase, accumulates at transcription pause sites through the tumor suppressor BRCA1. Here, we provide mechanistic insight into how SETX-BRCA1 resolves transcription-associated R-loops to prevent deleterious outcomes. Specifically, we show that full-length SETX unwinds R-loops with broad specificity and that the complex of BRCA1 and its obligatory partner BARD1 binds R-loops and...
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