Article
DSS1 restrains BRCA2's engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis.
Nature communications - 17 Aug 2024
Huang Yuxin, Li Wenjing, Foo Tzeh, Ji Jae-Hoon, Wu Bo, Tomimatsu Nozomi, Fang Qingming, Gao Boya, Long Melissa, Xu Jingfei, Maqbool Rouf, Mukherjee Bipasha, Ni Tengyang, Alejo Salvador, He Yuan, Burma Sandeep, Lan Li, Xia Bing, Zhao Weixing
Abstract excerpt
DSS1, essential for BRCA2-RAD51 dependent homologous recombination (HR), associates with the helical domain (HD) and OB fold 1 (OB1) of the BRCA2 DSS1/DNA-binding domain (DBD) which is frequently targeted by cancer-associated pathogenic variants. Herein, we reveal robust ss/dsDNA binding abilities in HD-OB1 subdomains and find that DSS1 shuts down HD-OB1's DNA binding to enable ssDNA targeting of the BRCA2-RAD51...
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