Article
BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage.
Nature communications - 10 Jun 2021
Vohhodina Jekaterina, Goehring Liana J, Liu Ben, Kong Qing, Botchkarev Vladimir V, Huynh Mai, Liu Zhiqi, Abderazzaq Fieda O, Clark Allison P, Ficarro Scott B, Marto Jarrod A, Hatchi Elodie, Livingston David M
Abstract excerpt
R-loop structures act as modulators of physiological processes such as transcription termination, gene regulation, and DNA repair. However, they can cause transcription-replication conflicts and give rise to genomic instability, particularly at telomeres, which are prone to forming DNA secondary structures. Here, we demonstrate that BRCA1 binds TERRA RNA, directly and physically via its N-terminal nuclear...
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