Article

Impact of N-terminal dimerization on formin homology 1 domain polymer dynamics and actin assembly

2025-11-23

Abstract excerpt

Many proteins contain intrinsically disordered regions (IDRs) that lack stable 3-dimensional structure. IDR behavior is poorly understood, leading to challenges for biochemical and computational analysis of IDR-containing proteins. Formins are a diverse set of homodimers containing an IDR — the FH1 domain — that facilitates polymerization of the cytoskeletal protein actin by increasing the local concentration of a...

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Literature Corpus work: 79b2ead6-37cb-5b30-9484-cda11a5e22bc
DOI: 10.1101/2025.11.21.689827

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