Article

Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail

2023-06-30

Abstract excerpt

<h4>Summary</h4> Cofilin family proteins have essential roles in remodeling the cytoskeleton through filamentous actin depolymerization and severing. The short unstructured N-terminal region of cofilin is critical for actin binding and harbors the major site of inhibitory phosphorylation. Atypically for a disordered sequence, the N-terminal region is highly conserved, but the aspects of cofilin functionality driv...

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Literature Corpus work: a070e9cd-26c3-5b6d-86eb-264592bd06a4
DOI: 10.1101/2023.06.30.547189

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