Article

Biochemical and structural analysis reveals the Neurofibromin (NF1) protein forms a high-affinity dimer

2019-09-05

Abstract excerpt

<h4>ABSTRACT</h4> Neurofibromin is the protein product of the NF1 gene which is mutated in the Rasopathy disease Neurofibromatosis Type I. Defects in NF1 lead to aberrant signaling through the RAS-MAPK pathway due to disruption of the Neurofibromin GTPase-activating function on RAS family small GTPases. Very little is known about the function of the majority of Neurofibromin—to date, biochemical and structural...

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Literature Corpus work: 9efbaab8-1a78-56f1-ba87-a9d0343f0a30
DOI: 10.1101/757856

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