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Article

FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation.

Nature structural & molecular biology - 1 Jan 2013

Thompson Morgan E, Heimsath Ernest G, Gauvin Timothy J, Higgs Henry N, Kull F Jon

Abstract excerpt

Formins are actin-assembly factors that act in a variety of actin-based processes. The conserved formin homology 2 (FH2) domain promotes filament nucleation and influences elongation through interaction with the barbed end. FMNL3 is a formin that induces assembly of filopodia but whose FH2 domain is a poor nucleator. The 3.4-Å structure of a mouse FMNL3 FH2 dimer in complex with tetramethylrhodamine-actin...

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Identifiers

PMID: 23222643
DOI: 10.1038/nsmb.2462
PMCID: PMC3876896

Genes

FMNL3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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