Article

Steric Regulation of Tandem Calponin Homology Domain Actin-Binding Affinity

2019-04-04

Abstract excerpt

<h4>ABSTRACT</h4> Tandem calponin homology (CH1-CH2) domains are common actin-binding domains in proteins that interact with and organize the actin cytoskeleton. Despite regions of high sequence similarity, CH1-CH2 domains can have remarkably different actin-binding properties, with disease-associated point mutants known to increase as well as decrease affinity for f-actin. To investigate features that affect CH1...

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Literature Corpus work: de141ff9-6e76-560a-b548-08c877177f71
DOI: 10.1101/598359

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