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Article

Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain.

Nature - 3 Feb 2005

Otomo Takanori, Tomchick Diana R, Otomo Chinatsu, Panchal Sanjay C, Machius Mischa, Rosen Michael K

Abstract excerpt

The conserved formin homology 2 (FH2) domain nucleates actin filaments and remains bound to the barbed end of the growing filament. Here we report the crystal structure of the yeast Bni1p FH2 domain in complex with tetramethylrhodamine-actin. Each of the two structural units in the FH2 dimer binds two actins in an orientation similar to that in an actin filament, suggesting that this structure could function as a...

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Identifiers

PMID: 15635372
DOI: 10.1038/nature03251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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