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Article

Molecular mechanism of actin filament elongation by formins.

Science (New York, N.Y.) - 12 Apr 2024

Oosterheert Wout, Boiero Sanders Micaela, Funk Johanna, Prumbaum Daniel, Raunser Stefan, Bieling Peter

Abstract excerpt

Formins control the assembly of actin filaments (F-actin) that drive cell morphogenesis and motility in eukaryotes. However, their molecular interaction with F-actin and their mechanism of action remain unclear. In this work, we present high-resolution cryo-electron microscopy structures of F-actin barbed ends bound by three distinct formins, revealing a common asymmetric formin conformation imposed by the...

Topics

Actin Cytoskeleton
Actins
Cryoelectron Microscopy
Formins
Profilins
Mutation
Schizosaccharomyces

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38603491
DOI: 10.1126/science.adn9560

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