Article

Conformational ensembles of the human intrinsically disordered proteome: Bridging chain compaction with function and sequence conservation

2023-05-08

Abstract excerpt

Intrinsically disordered proteins and regions (collectively IDRs) are pervasive across proteomes in all kingdoms of life, help shape biological functions, and are involved in numerous diseases. IDRs populate a diverse set of transiently formed structures, yet defy commonly held sequence-structure-function relationships. Recent developments in protein structure prediction have led to the ability to predict the thre...

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Literature Corpus work: e7fafa9b-bf47-5438-9aa4-76d561bfe48f
DOI: 10.1101/2023.05.08.539815

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