Article

Gamma-interferon-inducible lysosomal thiol reductase maintains cardiac immuno-metabolic homeostasis in heart failure

2022-07-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The lysosome is a central player in maintaining immuno-metabolic homeostasis. However, mechanistic insights into the regulation of lysosome-dependent immuno-metabolism in the heart are lacking. Lysosomal reductase Gamma Interferon-Inducible Thiol Reductase (GILT) is the only identified lysosomal reductase that controls diverse sets of lysosomal enzymes and cargoes. <h4>Metho...

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Literature Corpus work: 796419c2-a54f-5bde-abf6-60771e5753a0
DOI: 10.1101/2022.07.03.498477

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