Article

Targeting Metabolic Dysfunction and Inflammation with Sotagliflozin Reverses Diastolic Dysfunction in Experimental HFpEF

2025-12-01

Abstract excerpt

<h4>Background: </h4> Heart failure with preserved ejection fraction (HFpEF) is increasingly prevalent and strongly associated with cardiometabolic comorbidities including obesity, hypertension, and metabolic dysfunction. While SGLT2 inhibitors have demonstrated clinical benefits in HFpEF, the mechanisms underlying dual SGLT1/2 inhibition remain incompletely understood. <h4>Methods:</h4> We utilized a murine model...

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Literature Corpus work: 1eeca6dd-e0bf-5c2f-a22c-55db675b7949
DOI: 10.1101/2025.11.27.691021

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