Article

Lipid metabolism drives allele-specific early-stage hypertrophic cardiomyopathy

2023-11-15

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) results from pathogenic variants in sarcomeric protein genes, that increase myocyte energy demand and lead to cardiac hypertrophy. But it is unknown whether a common metabolic trait underlies the cardiac phenotype at early disease stage. This study characterized two HCM mouse models (R92W-TnT, R403Q-MyHC) that demonstrate differences in mitochondrial function at early disease stag...

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Literature Corpus work: 60f68ecc-d8cb-53ef-9ec1-4c1040324f86
DOI: 10.1101/2023.11.10.564562

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