Article

Early mitophagy defects and impaired mitochondrial energy metabolism drive target organ damage progression: lessons from the Fabry heart

2026-04-20

Abstract excerpt

Increased literature support the pathogenetic role of dysfunctional energetic metabolism in the setup and progression of organ damage and failure. Genetic diseases often offer the possibility to investigate pathogenetic mechanisms. In particular, excessive cardiac damage is the most frequent cause of mortality in Fabry disease (FD), a genetic condition caused by deficient α-galactosidase A (GLA) activity, leading...

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Literature Corpus work: 20451912-abac-5338-8cf1-e4402f2362dd
DOI: 10.64898/2026.04.15.718770

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