Article

Mitochondrial instability contributes to IFN-driven heart disease

2025-09-18

Abstract excerpt

<h4>Aims</h4> Type I interferons (IFNs) are linked to an increased risk of cardiovascular disease and are chronically elevated in systemic autoimmune diseases such as systemic lupus erythematosus (SLE). We evaluated the effect of chronic IFNa exposure on cardiac and cardiomyocyte function in order to better understand IFN-driven cardiac disease from the perspective of SLE. <h4>Methods and Results</h4> Administra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 99f32764-791c-5d0c-a138-17e77464a07a
DOI: 10.1101/2025.09.15.674036

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial instability contributes to IFN-driven heart diseaseDOI 10.1101/2025.09.15.674036Read

Inflammation in Cardiomyopathies: Cellular Mechanisms Across Cardiac Phenotype.Semantic proximity Read

Idiopathic Inflammatory Myopathies in the Post-COVID-19 Era: A Spotlight on Cardiac ImpairmentSemantic proximity Read

Inflammatory dilated cardiomyopathy (DCMI).Semantic proximity Read

Investigating the Profile of Patients with Idiopathic Inflammatory Myopathies in the Post-COVID-19 Period: Emphasizing Myocardial InjurySemantic proximity Read

Inflammation and mitochondria in the pathogenesis of chronic Chagas disease cardiomyopathySemantic proximity Read

Challenging the Conventional Treatment Initiation Paradigm: Early Detection of Irreversible Cellular Damage in Cardiac Biopsies of Fabry Disease Before the Formation of Gb3 Inclusion BodiesSemantic proximity Read

Interferon gamma signaling drives cardiac metabolic rewiringSemantic proximity Read

Crosstalk Between Innate Immunity and Autophagy in Viral Myocarditis Leading to Dilated CardiomyopathySemantic proximity Read

Sex differences in mitochondrial gene expression during viral myocarditisSemantic proximity Read

Gamma-interferon-inducible lysosomal thiol reductase maintains cardiac immuno-metabolic homeostasis in heart failureSemantic proximity Read

Chronic endoplasmic reticulum stress in myotonic dystrophy type 2 promotes autoimmunity via mitochondrial DNA releaseSemantic proximity Read

Single-cell transcriptomic analysis deciphers the inflammatory microenvironment characterized by CXCL9+ fibroblasts and ACKR1+ endothelial cells in immune-related myocarditisSemantic proximity Read