Article
ATG4D loss leads to late-onset cardiomyopathy and stress-induced heart failure in mice, and its repression marks maladaptive cardiac remodeling in humans
2025-09-30
Abstract excerpt
<h4>ABSTRACT</h4> In the last years, autophagy has emerged as an essential pathway for most cellular functions. Basal autophagy plays a protective role as a quality control mechanism by which damaged or noxious cellular components are degraded and cellular organelles are periodically renewed. Moreover, autophagic activity can be increased in situations of cellular stress, including nutrient or growth factor depri...
Topics
Open a Topic to create a Post that cites this publication.
- Autophagy in Disease and Therapy
- Calcium signaling and nucleotide metabolism
- Calpain Protease Function and Regulation
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Extracellular vesicles in disease
- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
Identifiers and source
- Literature Corpus work
- 4550f27e-d15d-57c1-b877-9ae28ceff387
- DOI
- 10.1101/2025.09.29.678527