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Article

ACE-inhibition induces a cardioprotective transcriptional response in the metabolic syndrome heart

26 Oct 2018

Abstract excerpt

Cardiovascular disease associated with metabolic syndrome has a high prevalence, but the mechanistic basis of metabolic cardiomyopathy remains poorly understood. We characterised the cardiac transcriptome in a murine metabolic syndrome (MetS) model (LDLR-/-; ob/ob, DKO) relative to the healthy, control heart (C57BL/6, WT) and the transcriptional changes induced by ACE-inhibition in those hearts. RNA-Seq,...

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PMID: 30385846
DOI: 10.1038/s41598-018-34547-9

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