Article

Mitochondrial Distress Signals at the Heart-Liver Interface: Molecular Links Between MASLD and Heart Failure

2026-07-20

Abstract excerpt

Mitochondrial distress signaling provides a mechanistic link between local organelle dysfunction and systemic cardio-hepatic remodeling. In metabolic dysfunction-associated steatotic liver disease (MASLD) and heart failure (HF), hepatic nutrient overload and cardiac energy-demand mismatch generate distinct but convergent disturbances in oxidative metabolism, mitochondrial dynamics, mitophagy, and redox control. Th...

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Literature Corpus work: 547a9e72-87d9-5e4a-b0e7-7ef34cd974a9
DOI: 10.20944/preprints202607.1463.v1

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