Article

Renalase inhibition regulates β cell metabolism to defend against acute and chronic stress

2024-06-13

Abstract excerpt

Renalase (Rnls), annotated as an oxidase enzyme, is a GWAS gene associated with Type 1 Diabetes (T1D) risk. We previously discovered that Rnls inhibition delays diabetes onset in mouse models of T1D in vivo , and protects pancreatic β cells against autoimmune killing, ER and oxidative stress in vitro . The molecular biochemistry and functions of Rnls are entirely uncharted. Here we find that Rnls inhibition defe...

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Literature Corpus work: 79e90ff0-578c-54df-9865-31d17c181ddf
DOI: 10.1101/2024.06.11.598322

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