Article

Cell type-specific adaptation of the SARS-CoV-2 spike

2023-12-20

Abstract excerpt

SARS-CoV-2 can infect various human tissues and cell types, principally via interaction with its cognate receptor ACE2. However, how the virus evolves in different cellular environments is poorly understood. Here, we used experimental evolution to study the adaptation of the SARS-CoV-2 spike to four human cell lines expressing different levels of key entry factors. After 20 passages, cell type-specific phenotypic...

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Literature Corpus work: 790e135d-e238-51b0-88fb-ca0792eb2d11
DOI: 10.1101/2023.12.20.572504

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