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Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike

15 May 2023

Abstract excerpt

Spike glycoprotein of SARS-CoV-2 mediates viral entry into host cells by facilitating virus attachment and membrane fusion. ACE2 is the main receptor of SARS-CoV-2 and its interaction with spike has shaped the virus' emergence from an animal reservoir and subsequent evolution in the human host. Many structural studies on the spike:ACE2 interaction have provided insights into mechanisms driving viral evolution...

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PMID: 37285618
DOI: 10.1016/j.sbi.2023.102619

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