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Article

Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases.

Journal of virology - 9 Mar 2022

Chaudhry M Zeeshan, Eschke Kathrin, Hoffmann Markus, Grashoff Martina, Abassi Leila, Kim Yeonsu, Brunotte Linda, Ludwig Stephan, Kröger Andrea, Klawonn Frank, Pöhlmann Stefan H, Cicin-Sain Luka

Abstract excerpt

Recent emergence of SARS-CoV-1 variants demonstrates the potential of this virus for targeted evolution, despite its overall genomic stability. Here we show the dynamics and the mechanisms behind the rapid adaptation of SARS-CoV-2 to growth in Vero E6 cells. The selective advantage for growth in Vero E6 cells is due to increased cleavage efficiency by cathepsins at the mutated S1/S2 site. S1/S2 site also...

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Chlorocebus aethiops
COVID-19
Cytopathogenic Effect, Viral
Furin
SARS-CoV-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Serine Endopeptidases

Spike Glycoprotein, Coronavirus

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Identifiers

PMID: 35019723
DOI: 10.1128/jvi.02186-21
PMCID: PMC8906416

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