Article

A selective sweep in the <i>Spike</i> gene has driven SARS-CoV-2 human adaptation

2021-02-17

Abstract excerpt

<h4>Summary</h4> While SARS-CoV-2 likely has animal origins 1 , the viral genetic changes necessary to adapt this animal-derived ancestral virus to humans are largely unknown, mostly due to low levels of sequence polymorphism and the notorious difficulties in experimental manipulations of coronavirus genomes. We scanned more than 182,000 SARS-CoV-2 genomes for selective sweep signatures and found that a distinct...

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Literature Corpus work: faf0afa2-27f4-5fa5-bbda-2c412bdc91e1
DOI: 10.1101/2021.02.13.431090

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