Article

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility

2020-10-27

Abstract excerpt

During the evolution of SARS-CoV-2 in humans a D614G substitution in the spike (S) protein emerged and became the predominant circulating variant (S-614G) of the COVID-19 pandemic 1 . However, whether the increasing prevalence of the S-614G variant represents a fitness advantage that improves replication and/or transmission in humans or is merely due to founder effects remains elusive. Here, we generated isogenic...

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Literature Corpus work: 26c4f119-0919-5065-9ff8-602087222200
DOI: 10.1101/2020.10.27.357558

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