Article

The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types

2020-06-15

Abstract excerpt

A novel isolate of the SARS-CoV-2 virus carrying a point mutation in the Spike protein (D614G) has recently emerged and rapidly surpassed others in prevalence. This mutation is in linkage disequilibrium with an ORF1b protein variant (P314L), making it difficult to discern the functional significance of the Spike D614G mutation from population genetics alone. Here, we perform site-directed mutagenesis to introduce...

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Literature Corpus work: 86e66187-9cc2-5bb6-a5b5-492b90692fc9
DOI: 10.1101/2020.06.14.151357

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