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Convergent Evolution and Host-Limiting Impacts of SARS-CoV-2 Revealed by Cellular Experiments.

Molecular biology and evolution - 29 Oct 2025

Zhang Ting, Tian Ren-Rong, Li Fengyi, Tang Xiaolu, He Wenbin, Hao Zhen-Ping, Zhuo Lin, Lu Jian, Lu Xuemei, Zheng Yong-Tang

Abstract excerpt

The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted the virus's remarkable ability to evolve and adapt in diverse hosts. Despite the observation of recurrent mutations and convergent evolution in the viral genome, the mechanisms driving these processes remain poorly understood, particularly in the context of diverse host environments and limited genomic...

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Identifiers

PMID: 41147188
DOI: 10.1093/molbev/msaf274
PMCID: PMC12619125

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