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Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection

16 Jul 2021

Abstract excerpt

SARS-CoV and SARS-CoV-2 encode spike proteins that bind human ACE2 on the cell surface to enter target cells during infection. A small fraction of humans encode variants of ACE2, thus altering the biochemical properties at the protein interaction interface. These and other ACE2 coding mutants can reveal how the spike proteins of each virus may differentially engage the ACE2 protein surface during infection. We...

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PMID: 34270613
DOI: 10.1371/journal.ppat.1009715

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