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Article

Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein.

PloS one - 1 Jan 2021

Heinzelman Pete, Romero Philip A

Abstract excerpt

Understanding how human ACE2 genetic variants differ in their recognition by SARS-CoV-2 can facilitate the leveraging of ACE2 as an axis for treating and preventing COVID-19. In this work, we experimentally interrogate thousands of ACE2 mutants to identify over one hundred human single-nucleotide variants (SNVs) that are likely to have altered recognition by the virus, and make the complementary discovery that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33979391
DOI: 10.1371/journal.pone.0251585
PMCID: PMC8115845

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