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Article

Altered hACE2 binding affinity and S1/S2 cleavage efficiency of SARS-CoV-2 spike protein mutants affect viral cell entry.

Virologica Sinica - 1 Aug 2023

Wang Ke, Pan Yu, Wang Dianbing, Yuan Ye, Li Min, Chen Yuanyuan, Bi Lijun, Zhang Xian-En

Abstract excerpt

SARS-CoV-2 variants are constantly emerging, hampering public health measures in controlling the number of infections. While it is well established that mutations in spike proteins observed for the different variants directly affect virus entry into host cells, there remains a need for further expansion of systematic and multifaceted comparisons. Here, we comprehensively studied the effect of spike protein...

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Identifiers

PMID: 37343929
DOI: 10.1016/j.virs.2023.06.005
PMCID: PMC10278895

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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