Article

Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis

2025-06-03

Abstract excerpt

<title>Abstract</title> <p>Mutations in somatic cells are inflicted by both extrinsic and intrinsic sources and contribute over time to cancer. Tobacco smoke contains chemical carcinogens that have been causatively implicated with cancers of the lung and head & neck1,2. APOBEC family DNA cytosine deaminases have emerged as endogenous sources of mutation in cancer, with hallmark mutational signatures (SBS2/SBS13)...

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Literature Corpus work: 780d8888-c68f-5dff-9976-78e8858418a8
DOI: 10.21203/rs.3.rs-5843684/v1

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