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Article

Dissection of Cancer Mutational Signatures with Individual Components of Cigarette Smoking.

Chemical research in toxicology - 17 Apr 2023

Mingard Cécile, Battey James N D, Takhaveev Vakil, Blatter Katharina, Hürlimann Vera, Sierro Nicolas, Ivanov Nikolai V, Sturla Shana J

Abstract excerpt

Tobacco smoke delivers a complex mixture of hazardous and potentially hazardous chemicals. Some of these may induce the formation of DNA mutations, which increases the risk of various cancers that display characteristic patterns of accumulated mutations arising from the causative exposures. Tracking the contributions of individual mutagens to mutational signatures present in human cancers can help understand...

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Topics

Humans
Cigarette Smoking
Benzo(a)pyrene
Tobacco Smoke Pollution
Mutation
Lung Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA

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Identifiers

PMID: 36976926
DOI: 10.1021/acs.chemrestox.3c00021
PMCID: PMC10114081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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