Article
APOBEC-Induced Mutagenesis in Cancer.
Annual review of genetics - 30 Nov 2022
Mertz Tony M, Collins Christopher D, Dennis Madeline, Coxon Margo, Roberts Steven A
Abstract excerpt
The initiation, progression, and relapse of cancers often result from mutations occurring within somatic cells. Consequently, processes that elevate mutation rates accelerate carcinogenesis and hinder the development of long-lasting therapeutics. Recent sequencing of human cancer genomes has identified patterns of mutations, termed mutation signatures, many of which correspond to specific environmentally induced...
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