Article
Mutational signatures associated with tobacco smoking in human cancer.
Science (New York, N.Y.) - 4 Nov 2016
Alexandrov Ludmil B, Ju Young Seok, Haase Kerstin, Van Loo Peter, Martincorena Iñigo, Nik-Zainal Serena, Totoki Yasushi, Fujimoto Akihiro, Nakagawa Hidewaki, Shibata Tatsuhiro, Campbell Peter J, Vineis Paolo, Phillips David H, Stratton Michael R
Abstract excerpt
Tobacco smoking increases the risk of at least 17 classes of human cancer. We analyzed somatic mutations and DNA methylation in 5243 cancers of types for which tobacco smoking confers an elevated risk. Smoking is associated with increased mutation burdens of multiple distinct mutational signatures, which contribute to different extents in different cancers. One of these signatures, mainly found in cancers derived...
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