Article

Tobacco smoke-induced DNA adducts sensitize genomes to APOBEC mutagenesis and carcinogenesis through nucleotide excision repair

2025-01-22

Abstract excerpt

<h4>SUMMARY</h4> Mutational processes are thought to act independently and additively. We challenge this view by demonstrating that DNA-adducting agents sensitize the genome to mutagenesis by APOBEC enzymes. A model tobacco carcinogen (NQO) triggers a 100-fold increase in APOBEC3B- catalyzed signature mutations and elevates oral carcinoma levels in vivo . A hallmark of this unidirectional synergy is strand-coord...

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Identifiers and source

Literature Corpus work: 18a000d4-b681-504d-9f86-4b37c8f6fd63
DOI: 10.1101/2025.01.18.633716

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