Article

APOBEC shapes tumor evolution and age at onset of lung cancer in smokers

2024-04-03

Abstract excerpt

<h4>ABSTRACT</h4> APOBEC enzymes are part of the innate immunity and are responsible for restricting viruses and retroelements by deaminating cytosine residues 1,2 . Most solid tumors harbor different levels of somatic mutations attributed to the off-target activities of APOBEC3A (A3A) and/or APOBEC3B (A3B) 3–6 . However, how APOBEC3A/B enzymes shape the tumor evolution in the presence of exogenous mutagenic pr...

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Literature Corpus work: 60626d42-e93c-5482-8567-2ca0ee127208
DOI: 10.1101/2024.04.02.587805

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