Article

Mutational signatures associated with tobacco smoking in human cancer

2016-05-03

Abstract excerpt

<h4>ABSTRACT</h4> Tobacco smoking increases the risk of at least 15 classes of cancer. We analyzed somatic mutations and DNA methylation in 5,243 cancers of types for which tobacco smoking confers an elevated risk. Smoking is associated with increased mutation burdens of multiple distinct mutational signatures, which contribute to different extents in different cancers. One of these signatures, mainly found in ca...

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Literature Corpus work: 05b47c37-49d6-5b56-a12a-db1c1cbee476
DOI: 10.1101/051417

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