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Article

Elevated APOBEC mutational signatures implicate chronic injury in etiology of an aggressive head-and-neck squamous cell carcinoma: a case report.

Journal of medical case reports - 30 Apr 2021

Patel Jena, den Breems Nicoline Y, Tuluc Madalina, Johnson Jennifer, Curry Joseph M, South Andrew P, Cho Raymond J

Abstract excerpt

BACKGROUND: Aggressive squamous cell carcinomas (SCCs) present frequently in the context of chronic skin injury occurring in patients with the congenital blistering disease recessive dystrophic epidermolysis bullosa. Recently, these cancers were shown to harbor mutation signatures associated with endogenous deaminases of the active polynucleotide cytosine deaminase family, collectively termed APOBEC, and...

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Identifiers

PMID: 33926553
DOI: 10.1186/s13256-021-02685-w
PMCID: PMC8086066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Elevated APOBEC mutational signatures implicate chronic injury in etiology of an aggressive head-and-neck squamous cell carcinoma: a case report.PMID 33926553Read ↗

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