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Human cancer genomes harbor the mutational signature of tobacco-specific nitrosamines NNN and NNK

2 Jul 2026

Abstract excerpt

BACKGROUND: Tobacco use is linked to multiple cancer types and a quarter of cancer deaths. Tobacco smoke contains numerous mutagenic chemicals such as polycyclic aromatic hydrocarbons (PAH), however, the mutagenicity of many chemicals in tobacco products remains underexplored. The tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN), both International...

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PMID: 38979250
DOI: 10.1186/s13073-026-01685-z

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