Article
The complexity of tobacco smoke-induced mutagenesis in head and neck cancer.
Nature genetics - 1 Apr 2025
Torrens Laura, Moody Sarah, de Carvalho Ana Carolina, Kazachkova Mariya, Abedi-Ardekani Behnoush, Cheema Saamin, Senkin Sergey, Cattiaux Thomas, Cortez Cardoso Penha Ricardo, Atkins Joshua R, Gaborieau Valérie, Chopard Priscilia, Carreira Christine, Abbasi Ammal, Bergstrom Erik N, Vangara Raviteja, Wang Jingwei, Fitzgerald Stephen, Latimer Calli, Diaz-Gay Marcos, Jones David, Teague Jon, Ribeiro Pinto Felipe, Kowalski Luiz Paulo, Polesel Jerry, Giudici Fabiola, de Oliveira José Carlos, Lagiou Pagona, Lagiou Areti, Vilensky Marta, Mates Dana, Mates Ioan N, Arantes Lidia M, Reis Rui, Podesta Jose Roberto V, von Zeidler Sandra V, Holcatova Ivana, Curado Maria Paula, Canova Cristina, Fabianova Elenora, Rodríguez-Urrego Paula A, Humphreys Laura, Alexandrov Ludmil B, Brennan Paul, Stratton Michael R, Perdomo Sandra
Abstract excerpt
Tobacco smoke, alone or combined with alcohol, is the predominant cause of head and neck cancer (HNC). We explore how tobacco exposure contributes to cancer development by mutational signature analysis of 265 whole-genome sequenced HNC samples from eight countries. Six tobacco-associated mutational signatures were detected, including some not previously reported. Differences in HNC incidence between countries...
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